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Rev. Assoc. Med. Bras. (1992) ; 62(supl.1): 25-28, Oct. 2016. graf
Article in English | LILACS | ID: biblio-829563

ABSTRACT

ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to discuss the factors that can guide the decision-making on referring or not a patient to HSCT. Three cases of MDS, two of which were submitted to HSCT are presented. We intend to report the difficulties in referring patients with MDS to transplant and the prognostic factors that contribute to define eligibility.


RESUMO O transplante de células-tronco hematopoéticas (TCTH) é a única alternativa curativa para Síndrome Mielodisplásica (SMD), porém muitos pacientes não são elegíveis para esta opção, pois existem diversos fatores limitantes, principalmente no caso de pacientes com SMD de baixo risco. O objetivo do estudo é discutir os fatores que podem orientar a decisão no encaminhamento ou não para o TCTH. São apresentados três casos de SMD, dos quais dois foram submetidos ao TCTH. Nos propomos a relatar as dificuldades no encaminhamento dos pacientes com SMD ao transplante e os fatores prognósticos que contribuem para definir a elegibilidade.


Subject(s)
Humans , Male , Female , DNA Damage/physiology , Oxidative Stress/physiology , Hematopoietic Stem Cell Transplantation/methods , Lymphoma/surgery , Multiple Myeloma/surgery , Reference Values , Time Factors , Transplantation, Autologous/methods , Biomarkers , Case-Control Studies , Analysis of Variance , Treatment Outcome , Lymphoma/genetics , Lymphoma/mortality , Malondialdehyde/analysis , Multiple Myeloma/genetics , Multiple Myeloma/metabolism
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